Zhejiang Heben Successfully Improves Synthetic Process of Difenoconazole

November Issue of Fungicides China News has been published by CCM recently, presenting that Zhejiang Heben Pesticide & Chemicals Co., Ltd. (Zhejiang Heben), one of the leading fungicide manufacturers in China, has successfully completed the innovation on synthetic process of difenoconazole.

Conventionally, difenoconazole is developed from 2,4-Dichloroacetophenone followed by etherification, bromination, ketal reaction and nucleophilic substitution, with an overall yield of about 70%.

However, Zhejiang Heben's new process of synthesizing difenoconazole has more advantages than the conventional method mentioned above. In detail, beginning with 3,4' -dichlorodiphenyl ether, difenoconazole is synthesized by acylation, condensation and cyclization, with a total yield of about 81%. What's more, the purity of difenoconazole can reach over 97%. Besides high yield and purity, this new method has other advantages, such as easy operation, short reaction time, little "three wastes", etc.

Zhejiang Heben constructed a 100t/a difenoconazole technical production line as early as 2007, thereafter the  company has gradually expanded its capacity to the current about 450t/a, says Mr. Li, Sales Manager of Zhejiang Heben. Moreover, most difenoconazole technical of Zhejiang Heben is exported to the overseas market.

Check the specific synthesis route of difenoconazole in CCM’s Fungicides China News 1111, together with major headline news below:

-Shandong Dacheng continues to show a financial deficit of about USD4.88 million (RMB31.01 million) in Q3 2011.

-Lier Chemical's revenue has witnessed a huge increase of 80.06%, but its net profit has dropped by 15.11% year on year in the first three quarters of 2011.

-Yangnong Chemical' net profit has witnessed surge, up 72.63% year on year in Q3 2011; however, its net profit in the first three quarters of this year has slipped by 14.50%.

-Jiangsu Huifeng plans to establish a subsidiary to significantly improve the competitiveness of its fluorine-containing pesticides and extend the industrial chain in the long run.

-Shenyang Sciencreat has successfully obtained the temporary registration certificates of pyrametostrobin 95% TC and 20% SC in Sept. 2011.

-Wuhan Kernel will surely usher in a new phase of the rapid development with the infusion of new blood in the near future.

-Zhengye Zhongnong is making particular efforts to improve its development of fungicide --technical and formulations at present.

-Jiangsu Sword's microwave method for the preparation of 1,2,4-triazolylsodium and 1,2,4-1K-triazole has been granted the national patent recently.

-Zhejiang Heben has successfully completed the innovation on synthetic process of difenoconazole.

-The ex-factory price of mancozeb 90% TC has decreased by 22.25% in early Nov. 2011 over last month.

-Chemical pesticide application will witness a further decline in the domestic market in 2012.

… …

About CCM

CCM is dedicated to market research in China, Asia-Pacific Rim and global market. With a staff of more than 150 dedicated highly-educated professionals. CCM offers Market Data, Analysis, Reports, Newsletters, Buyer-Trader Information, Import/Export Analysis all through its new proprietary product ValoTracer.

For more information, please visit http://www.cnchemicals.com.

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Tel: 86-20-37616606

Email: econtact@cnchemicals.com

Source: http://www.cnchemicals.com/PressRoom/PressRoomDetail_c_833.html

Zhejiang Heben Innovates Synthetic Process of Difenoconazole

Zhejiang Heben Pesticide & Chemicals Co., Ltd. (Zhejiang Heben), one of the leading fungicide manufacturers in China, has successfully completed the innovation on synthetic process of difenoconazole, and this project has been checked and accepted by the Science Technology Department of Zhejiang Province smoothly, according to CCM’s November Issue of Fungicides China News.

Difenoconazole, a triazole fungicide with high efficiency, low toxicity and broad spectrum, is widely applied to prevent and control various diseases, such as sheath blight, rust, early blight, powdery mildew, leaf spot, scab, etc., in the fields of wheat, rice, tomato, pepper, grape, citrus and so forth.

It is well known that Syngenta is the first company developing difenoconazole which is conventionally prepared from 2,4-Dichloroacetophenone followed by etherification, bromination, ketal reaction and nucleophilic substitution, with an overall yield of about 70%.

However, Zhejiang Heben's new process of synthesizing difenoconazole is relatively more advantageous than the conventional method mentioned above. In detail, beginning with 3，4' -dichlorodiphenyl ether, difenoconazole is synthesized by acylation, condensation and cyclization, with a total yield of about 81%. What's more, the purity of difenoconazole can reach over 97%.

Besides high yield and purity, this new method still has other advantages, such as easy operation, short reaction time, little "three wastes", etc., to improve the synthetic process of difenoconazole, according to Zhejiang Heben. The specific synthesis route of difenoconazole is as follows.

As description in the article on the study of new synthetic process of difenoconazole, the result shows that  isobutyl alcohol, a low-boiling solvent, is substituted for a high-boiling one--dimethylamide (DMF) in the condensation reaction and the former is easily recovered compared with the latter.

In cyclization reaction, replacing p-toluenesulfonic acid with the homemade composite catalyst can not only shorten the reaction time but also reduce the consumption of 1,2-Propanediol to a great extent; the yield of difenoconazole is risen by 5% accordingly when using homemade composite catalyst of Zhejiang Heben.

Last but not least, adopting composite solvent crystallization technique achieves the breakthrough in crystallization problem in the purification process of difenoconazole, which can also greatly increase product content.

Zhejiang Heben constructed a 100t/a difenoconazole technical production line as early as 2007, thereafter the  company has gradually expanded its capacity to the current about 450t/a, says Mr. Li, Sales Manager of Zhejiang Heben. Moreover, most difenoconazole technical of Zhejiang Heben is exported to the overseas market.

Source: Fungicides China News 1111

http://www.cnchemicals.com/Newsletter/NewsletterDetail.aspx?id=2

Main content of Fungicides China News 1111:

Shandong Dacheng continues financial deficit in Q3 2011

Lier Chemical: Revenue jumps but net profit drops from Jan. to Sept. 2011

Yangnong Chemical surges in Q3 net profit

Jiangsu Huifeng to establish subsidiary in Lianyungang of Jiangsu

Shenyang Sciencreat successfully registers pyrametostrobin

New blood brings more vitality to Wuhan Kernel 

Zhengye Zhongnong improving fungicide development

Jiangsu Sword wins a national invention patent recently

Zhejiang Heben innovates synthetic process of difenoconazole 

Ex-factory price of mancozeb 90% TC sharply declines in early Nov. 2011

Ningnanmycin promotes well especially in tobacco virus disease control market

Pesticide output up 15.7% year on year in the first three quarters of 2011

Supply of 1,2,4-triazole under tight recently

Autumn-winter sowing completes 65% by late Oct. 2011

Domestic chemical pesticide application to continue decreasing in 2012

Fungicides China News, a monthly publication issued by CCM International on 10th of every month, provides a wealth of exclusive information and analysis, research and development dynamics of domestic competitors, analysis on import and export of key products, cooperative opportunities with domestic and foreign companies, and market information of foreign patent-expired products.

About CCM

CCM is dedicated to market research in China, Asia-Pacific Rim and global market. With a staff of more than 150 dedicated highly-educated professionals. CCM offers Market Data, Analysis, Reports, Newsletters, Buyer-Trader Information, Import/Export Analysis all through its new proprietary product ValoTracer.

For more information, please visit http://www.cnchemicals.com.

CCM International Ltd.
Guangzhou CCM Information Science & Technology Co., Ltd.
17th Floor, Huihua Commercial & Trade Mansion, No.80 Xianlie Zhong Road, Guangzhou 510070, China

Tel: 86-20-37616606

Email: econtact@cnchemicals.com

Source: http://www.cnchemicals.com/PressRoom/PressRoomDetail_w_815.html

Domestic Market of Triazole Fungicides Keeps Growing

CCM’s October Issue of Fungicides China News has been released recently. The market dynamic of triazole fungicides in China attracts people’s attention.

Triazole fungicides rank the first place by market value in all the categories of fungicides in China in 2010. Domestic consumption of triazole fungicides has increased by 10.5% in 2010 compared with that in previous years. It is estimated that China’s consumption of triazole fungicides will continue to grow in the future.

China's total capacity of triazole fungicides has exceeded 50,000t/a in 2010 with the capacity expansion and the launch of many new production lines in recent years. The total market value of triazole fungicides has grown to about USD409 million in 2010, up 7.1% and 31.5% respectively compared with that in 2009 and 2008. The top three triazole fungicides by market value were tebuconazole, propiconazole and triadimefon in 2010.

It is estimated that both the output and domestic consumption of triazole fungicides will continue to see stable growth in the next few years with the enhanced promotion and extended control spectrum. What's more, some new triazole fungicides like epoxiconazole, the second largest variety of triazole fungicides in the global pesticide market, are expected to witness high demand growth in China in the future.

More news in CCM’s October Issue of Fungicides China News:

-Jiangsu Huifeng's net profit in H1 2011 has plummeted by 12.72% year on year.

-Qianjiang Biochemical has made great achievements in its revenue and net profit in H1 2011.

-Huaxing Chemical has seriously suffered financial deficit of about USD3.16 million in H1 2011, but its fungicide business has witnessed surge.

-Shandong's pesticide industry has witnessed tortuous recovery in the first half of 2011.

-The demand for fungicides to control major diseases in the fields of cotton, vegetables, fruits and late rice is on the rise at home recently.

-Triazole fungicides have ranked the first place by market value in China in 2010, and the consumption will continue growing in the future.

-Prochloraz is unsuitable to be blindly expanded at present mainly due to the current large capacity, slow-growth export and many competitive products.

-Changqing Agrochemical aims to speed up the development of fungicides to further enrich its product mix and explore new profit growth points in the near future.

-China's fungicide export volume has increased by 22.0% year on year in the first seven months of 2011.

-China's export volume of ethephon technical has ranked the fourth place among the top 20 export pesticide technical in July 2011.

-Shanghai Nongle has been energetically promoting the phenazino-1-carboxylic acid 1% SC in the domestic main planting areas of vegetables, fruits and grains.

-The supply of cymoxanil technical is very tight at present and its ex-factory price has witnessed increase in early Oct. 2011.

-Though the ex-factory prices of most fungicides in the domestic market have witnessed decrease to some extent in early Oct. 2011, four fungicides break through the industrial price reduction.

-Late rice diseases and insect pests in the middle and late growth stages of late rice will occur seriously in Zhejiang Province.

-Potato late blight has occurred severely in Gansu Province since mid-Aug. 2011.

For more information about CCM’s October Issue of Fungicides China News, please feel free to contact us at econtact@cnchemicals.com.

 (Guangzhou China, October 12, 2011)

About CCM

CCM is dedicated to market research in China, Asia-Pacific Rim and global market. With a staff of more than 150 dedicated highly-educated professionals. CCM offers Market Data, Analysis, Reports, Newsletters, Buyer-Trader Information, Import/Export Analysis all through its new proprietary product ValoTracer.
Please visit http://www.cnchemicals.com for more information or contact econtact@cnchemicals.com

CCM International Ltd.
Guangzhou CCM Information Science & Technology Co., Ltd.
17th Floor, Huihua Commercial & Trade Mansion, No.80 Xianlie Zhong Road, Guangzhou 510070, China